Functional hyper-networks are widely used in brain disease diagnosis and classification studies. However, the existing research on hyper-network construction lacks the ability to interpret the grouping effect or only considers the information of group level information of brain regions, the hyper-network constructed in this way may lose some useful connections or contain some false information. Therefore, considering the group structure problem of brain regions, the sparse group Lasso (Least absolute shrinkage and selection operator) (sgLasso) method was introduced to further improve the construction of hyper-network. Firstly, the hyper-network was constructed by using the sgLasso method. Then, two groups of attribute indicators specific to the hyper-network were introduced for feature extraction and feature selection. The indictors are the clustering coefficient based on single node and the clustering coefficient based on a pair of nodes. Finally, the two groups of features with significant difference obtained after feature selection were subjected to multi-kernel learning for feature fusion and classification. The experimental results show that the proposed method achieves 87.88% classification accuracy by using the multi-feature fusion, which indicates that in order to improve the construction of hyper-network of brain function, the group information should be considered, but the whole group information cannot be forced to be used, and the group structure can be appropriately expanded.

The feature representation extracted from the functional connection network based on single brain map template is not sufficient to reveal complex topological differences between patient group and Normal Control (NC) group. However, the traditional multi-template-based functional brain network definitions mostly use independent templates, ignoring the potential topological association information in functional brain networks built with each template. Aiming at the above problems, a multi-level brain map template and a method of Relationship Induced Sparse (RIS) feature selection model were proposed. Firstly, an associated multi-level brain map template was defined, and the potential relationship between templates and network structure differences between groups were mined. Then, the RIS feature selection model was used to optimize the parameters and extract the differences between groups. Finally, the Support Vector Machine (SVM) method was used to construct classification model and was applied to the diagnosis of patients with depression. The experimental results on the clinical diagnosis database of depression in the First Hospital of Shanxi University show that the functional brain network based on multi-level template achieves 91.7% classification accuracy by using the RIS feature selection method, which is 3 percentage points higher than that of traditional multi-template method.